THE IMPLICATION OF TARGETING PD-1:PD-L1 PATHWAY IN TREATING SEPSIS THROUGH IMMUNOSTIMULATORY AND ANTI-INFLAMMATORY PATHWAYS

The implication of targeting PD-1:PD-L1 pathway in treating sepsis through immunostimulatory and anti-inflammatory pathways

Sepsis currently remains a major contributor to mortality in the intensive care unit (ICU), with 48.9 million cases reported globally and a mortality rate of 22.5% in 2017, accounting for almost 20% of all-cause mortality worldwide.This highlights the urgent need to improve the understanding and treatment of this condition.Sepsis is now recognized

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Effect of empagliflozin on cardiac remodelling in South Asian and non-South Asian individuals: insights from the EMPA-HEART CardioLink-6 randomised clinical trial

Abstract Background This exploratory sub-analysis of the EMPA-HEART CardioLink-6 trial examined whether the previously reported benefit of the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin on left ventricular (LV) mass (LVM) regression differs between individuals of South Asian and non-South Asian ethnicity.Methods EMPA-HEART Cardi

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Forensic analysis of video steganography tools

Steganography is the art and science of concealing information in such a way that only the sender and intended recipient of a message should be aware of its presence.Digital steganography has been used in the past on a variety of media including executable files, audio, text, games and, notably, images.Additionally, there is increasing research int

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Zinc pyrithione exposure compromises oocyte maturation through involving in spindle assembly and zinc accumulation

Zinc Pyrithione (ZPT), a Food and Drug Administration (FDA) approved chemical, is widely used for topical antimicrobials and kryolan anti shine powder cosmetic consumer products, including anti-dandruff shampoos.ZPT and its degraded byproducts have detected in large quantities in the environment, and identified to pose healthy risks on aquatic orga

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